Research & Publications

Quantification of Information Gained by Linking Claims Data to an Electronic Health Record Cohort of Patients With Metastatic Breast Cancer

A Retrospective Observational Study Characterizing People with Type 1 Diabetes Using CGM in a Linked Electronic Health Record—Continuous Glucose Monitoring Dataset

Surveying a New Multi-Institution Clinical Data Research Network

Mortality Risk Factors Among Patients With Cirrhosis and a Low Model for End-Stage Liver Disease Sodium Score (≤15): An Analysis of Liver Transplant Allocation Policy Using Aggregated Electronic Health Record Data

Health Inequalities in the Use of Telehealth in the United States in the Lens of COVID-19

PCORnet® 2020: current state, accomplishments, and future directions

Efficacy of immune checkpoint inhibitor therapy in patients with RET fusion-positive non-small-cell lung cancer

Amivantamab compared with real-world therapies in patients with NSCLC with EGFR Exon 20 insertion mutations who have progressed after platinum doublet chemotherapy

Ten rules for conducting retrospective pharmacoepidemiological analyses: example COVID-19 study

Joining Health Care and Homeless Data Systems Using Privacy-Preserving Record-Linkage Software

Relative Effectiveness of Adjuvanted Trivalent vs. Egg-derived Quadrivalent and High-dose Trivalent Influenza Vaccines in Preventing Influenza-related Medical Encounters in US Adults ≥65 Years (2017–2019 Seasons)

The Utility of Data Tokenization in Clinical Trials

Ciox, Sentara Healthcare Pilot Data Access Tool to Improve Maternal Health

Real-world medication adherence to tafamidis treatment in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) in the US Medicare population

Real-world analysis of healthcare resource utilization by patients with X-linked myotubular myopathy (XLMTM) in the United States

LUMINATE-103: Real-world treatment patterns and outcomes of patients with epidermal growth factor receptor mutant, non-squamous locally advanced/metastatic non-small cell lung cancer: Pooled analysis of large US electronic health record datasets

Empowering Mothers with Access to Maternity Care Records through Public-Private Partnerships

Kidney and Cardiovascular Effectiveness of Empagliflozin Compared With Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes

Prediction models for glaucoma in a multicenter electronic health records consortium: the Sight Outcomes Research Collaborative

Higher SARS-CoV-2 spike antibody levels are associated with reduced risk of subsequent symptomatic and severe COVID-19: A real-world data study

Fit-for-purpose and scalable strategy to address mortality completeness for oncology research: Comparison of multiple real-world sources with the National Death Index

Using privacy-preserving record linkage to incorporate real-world data into a Phase IV long-term follow-up of individuals with SMA (WeSMA)

Concordance With Screening and Treatment Guidelines for Chronic Kidney Disease in Type 2 Diabetes

Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage

Adherence and persistence to tafamidis treatment among Medicare beneficiaries in the presence of a patient assistance program

Privacy preserving record linkage for public health action: opportunities and challenges

Real-World Trends in SARS-CoV-2 Antibody Levels and Their Link to Subsequent COVID-19 in the United States

Kidney and Cardiovascular Effectiveness of SGLT2 Inhibitors vs GLP-1 Receptor Agonists in Type 2 Diabetes

Real-World Analysis of Major Depressive Disorder in Clinical Trial Participants

Linking The Cancer Imaging Archive and GenBank to the National Clinical Cohort Collaborative

SARS-CoV-2 SPIKE Antibody Levels can Indicate Immuno-Resilience to Re-infection: a Real-World Study

Race, Social Determinants of Health, and the Quality of Diabetic Eye Care

Accuracy of privacy preserving record linkage for real world data in the United States: a systemic review

Real-world treatment and outcomes for EGFR WT advanced/metastatic non-squamous non-small cell lung cancer: pooled analysis from project LUMINATE-101

Overall Survival with Apalutamide Versus Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer

Real-world comparison of deep prostate-specific antigen response in patients with metastatic castration-sensitive prostate cancer treated with apalutamide or enzalutamide

A comparison of prostate-specific antigen response in patients with metastatic castration-sensitive prostate cancer initiated on apalutamide vs abiraterone acetate in linked clinical and claims databases

Data Linkage Multiplies Research Insights Across Diverse Healthcare Sectors

Privacy-Preserving Record Linkage as a Valuable Method to Build More Complete Treatment Journeys

Sex differences in COVID-19 mortality: A large US-based cohort study (2020–2022)

Best Practices in Evolving Privacy Frameworks for Patient Age Data: Census Data Study

Digital Musculoskeletal Program Is Associated With Decreased Joint Replacement Rates

Optic Neuritis and Cranial Neuropathies Diagnosis Rates before Coronavirus Disease 2019, in the Initial Pandemic Phase, and Post-Vaccine Introduction

Privacy-preserving record linkage across disparate institutions and datasets to enable a learning health system: The national COVID cohort collaborative (N3C) experience

Creation of a data commons for substance misuse related health research through privacy-preserving patient record linkage between hospitals and state agencies

Social and Health Information Platform: Piloting a Standards-Based, Digital Platform Linking Social Determinants of Health Data into Clinical Workflows for Community-Wide Use

Real‑world Analysis of Healthcare Resource Utilization by Patients With X‑linked Myotubular Myopathy (XLMTM) in the United States

One-Year Adverse Outcomes Among US Adults With Post–COVID-19 Condition vs Those Without COVID-19 in a Large Commercial Insurance Database

Use of large-scale privacy protecting record linkages for data sharing to enhance

Excess Deaths for Republicans and Democrats During the COVID-19 Pandemic

Assessing the impact of privacy-preserving record linkage on record overlap and patient demographic and clinical characteristics in PCORnet®, the National Patient-Centered Clinical Research Network

Establishing a framework for privacy-preserving record linkage among electronic health record and administrative claims databases within PCORnet

Cancer Research Needs Better Databases

Real-World Evidence Primer

Real-World Matching Performance of Deidentified Record-Linking Tokens

Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States

Evaluation of the Association Between Medicare Eligibility and Excess Deaths During the COVID-19 Pandemic in the US

Trends In Outpatient Mental Health Services Use Before And During The COVID-19 Pandemic

Amivantamab compared with real-world therapies in patients with NSCLC with EGFR Exon 20 insertion mutations who have progressed after platinum doublet chemotherapy

Variability in comorbidities and health services use across homeless typologies: multicenter data linkage between healthcare and homeless systems

Relative Effectiveness of the Cell-derived Inactivated Quadrivalent Influenza Vaccine Versus Egg-derived Inactivated Quadrivalent Influenza Vaccines in Preventing Influenza-related Medical Encounters During the 2018–19 Influenza Season in the US

Primary Care in the COVID-19 Pandemic: Chronic Care Management During the COVID-19 Pandemic

Intra-household Transmission of Infectious Disease and Gender Inequality

The Impact of COVID-19 on the Use of Preventive Health Care

Analysis of Electronic Medical Record Data Shows Significantly Higher Rates of COVID-19 Infection among Hispanic and Black Patients

Further Evidence That COVID-19 Disproportionately Impacts African American, Hispanic, and Low-Income Populations

Socioeconomic Network Heterogeneity and Pandemic Policy Response

Computable Phenotype Implementation for a National, Multicenter Pragmatic Clinical Trial: Lessons Learned From ADAPTABLE

Daily Deaths During Coronavirus Pandemic by State

Use of Administrative Claims to Assess Outcomes and Treatment Effect in Randomized Clinical Trials for Transcatheter Aortic Valve Replacement: Findings from the Extending Trial-Based Evaluations of Medical Therapies Using Novel Sources of Data Study

Privacy-Preserving Record Linkage to Identify Fragmented Electronic Medical Records in the All of Us Research Program

Health Care Utilization Among Homeless Veterans in Chicago

The Patient-Centered Outcomes Research Network Antibiotics and Childhood Growth Study: Implementing Patient Data Linkage

Patients With Persistently Low MELD-Na Scores Continue to be at Risk of Liver Related Death

Administrative Claims Data to Support Pragmatic Clinical Trial Outcome Ascertainment on Cardiovascular Health

The Hispanic Paradox in Patients With Liver Cirrhosis: Current Evidence from a Large Regional Retrospective Cohort Study

Depressive Symptom Prevalence After Intracerebral Hemorrhage: A Multi-Center Study

A Novel Patient Recruitment Strategy: Patient Selection Directly From the Community Through Linkage to Clinical Data

Disease Outcomes and Care Fragmentation among Patients With Systemic Lupus Erythematosus

Validity of Cardiovascular Data From Electronic Sources

Payment Reform Needed to Address Health Disparities of Undiagnosed Diabetic Retinopathy in the City of Chicago

Does Spatial Access to Primary Care Affect Emergency Department Utilization for Nonemergent Conditions?

Distance from Hospital Impacts Adverse Event Detection After Outpatient Endoscopy

An Evaluation of Recurrent Diabetic Ketoacidosis, Fragmentation of Care, and Mortality Across Chicago, Illinois

Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago

Explore external research studies made possible by connected real-world data

Race, Social Determinants of Health, and the Quality of Diabetic Eye Care

Real-World Trends in SARS-CoV-2 Antibody Levels and Their Link to Subsequent COVID-19 in the United States

Kidney and Cardiovascular Effectiveness of SGLT2 Inhibitors vs GLP-1 Receptor Agonists in Type 2 Diabetes

Sex differences in COVID-19 mortality: A large US-based cohort study (2020–2022)

Adherence and persistence to tafamidis treatment among Medicare beneficiaries in the presence of a patient assistance program

Privacy preserving record linkage for public health action: opportunities and challenges

Using privacy-preserving record linkage to incorporate real-world data into a Phase IV long-term follow-up of individuals with SMA (WeSMA)

Concordance With Screening and Treatment Guidelines for Chronic Kidney Disease in Type 2 Diabetes

Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage

Prediction models for glaucoma in a multicenter electronic health records consortium: the Sight Outcomes Research Collaborative

Higher SARS-CoV-2 spike antibody levels are associated with reduced risk of subsequent symptomatic and severe COVID-19: A real-world data study

Fit-for-purpose and scalable strategy to address mortality completeness for oncology research: Comparison of multiple real-world sources with the National Death Index

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