Research & Publications

This year, a study of ten million people revealed the power of longitudinal research. A team mined a vast medical database of US military personnel, including tissue samples and health records collected over 20 years.

Publication

Cancer Research Needs Better Databases

To learn from the evolving lessons of addressing the COVID-19 pandemic and to bolster the future use of real-world data (RWD) and real-world evidence (RWE), The FDA Foundation, in collaboration with the International Society for Pharmacoepidemiology (ISPE), created The COVID-19 Real-World Evidence Primer.

Publication

Real-World Evidence Primer

Elmer V Bernstam, Reuben Joseph Applegate, Alvin Yu, Deepa Chaudhari, Tian Liu, Alex Coda, Jonah Leshin. Objective: Our objective was to evaluate tokens commonly used by clinical research consortia to aggregate clinical data across institutions.

Publication

Real-World Matching Performance of Deidentified Record-Linking Tokens

Wataru Ando, Takeshi Horii, Takayuki Uematsu, Hideaki Hanaki, Koichiro Atsuda & Katsuya Otori. The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from January 1, 2020 to November 30, 2020.

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Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States

Jacob Wallace, PhD; Anthony Lollo, PhD; Chima D. Ndumele, PhD. In the US, COVID-19 is responsible for hundreds of thousands of excess deaths,1 which has led to considerable interest in strategies to mitigate its impact.

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Evaluation of the Association Between Medicare Eligibility and Excess Deaths During the COVID-19 Pandemic in the US

Jane M. Zhu, Renae Myers, K. John McConnell, Ximena Levander, and Sunny C. Lin. The COVID-19 pandemic disrupted mental health services delivery across the US, but the extent and implications of these disruptions are unclear.

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Trends In Outpatient Mental Health Services Use Before And During The COVID-19 Pandemic

Amivantamab is an epidermal growth factor receptor (EGFR)-MET bispecific antibody with immune cell-directing activity.

Publication

Amivantamab compared with real-world therapies in patients with NSCLC with EGFR Exon 20 insertion mutations who have progressed after platinum doublet chemotherapy

William E. Trick, Fred Rachman, Keiki Hinami, Jennifer C. Hill, Craig Conover, Lisa Diep, Howard S. Gordon, Abel Kho, David O. Meltzer, Raj C. Shah, Ed Stellon, Padma Thangaraj & Peter S. Toepfer

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Variability in comorbidities and health services use across homeless typologies: multicenter data linkage between healthcare and homeless systems

Constantina Boikos, Lauren Fischer, Dan O’Brien, Joe Vasey, Gregg C Sylvester, James A Mansi. This study estimated the relative vaccine effectiveness (rVE) of ccIIV4 versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018–2019 US season.

Publication

Relative Effectiveness of the Cell-derived Inactivated Quadrivalent Influenza Vaccine Versus Egg-derived Inactivated Quadrivalent Influenza Vaccines in Preventing Influenza-related Medical Encounters During the 2018–19 Influenza Season in the US

Aaron Baum

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Primary Care in the COVID-19 Pandemic: Chronic Care Management During the COVID-19 Pandemic

Xinming Du. The study examined how intrahousehold transmission of COVID-19 is impacted by gender inequities.

Publication

Intra-household Transmission of Infectious Disease and Gender Inequality

Katie Martin, Daniel Kurowski, Phillip Given, Kevin Kennedy, Elianna Clayton. HCCI's work shows submitted claims for most preventive services we examined, such as mammography and childhood immunizations exhibited significant declines in 2020 compared to 2019, particularly mid-March through mid-April. Even by June 2020 utilization of many preventive services appeared to be running below 2019 levels

Publication

The Impact of COVID-19 on the Use of Preventive Health Care

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